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TUPDC0302 - Poster Discussion Session
Perceptions and attitudes about PrEP among seronegative partners and the potential of sexual disinhibition associated with the use of PrEP
Presented by Wayne Duffus (United States).
A. Tripathi1, O. Whiteside2, C. Scanlon2, W. Duffus2
1University of South Carolina, Epidemiology and Biostatistics, Columbia, United States, 2South Carolina Department of Health and Environmental Control, Bureau of Disease Control, Columbia, United States
Background: Preexposure
prophylaxis (PrEP) is a promising biomedical strategy to reduce HIV transmission. However, many caveats such as the potential risk of sexual disinhibition
and non-compliance need to be considered. The objective of this survey was to explore
the sociodemographic and behavioral factors associated with the adoption of
PrEP among both MSM and heterosexual seronegative partners.
Methods: Pre-piloted
self-administered survey was conducted among seronegative partners in a Ryan
White Clinic in South Carolina from 2010-2011. Bivariate and multivariable
analyses were used to explore the data.
Results: A total of 89
seronegative partners completed the survey. The median age was 42 years (IQR: 32-50) and a
majority were males (56%), blacks (70%) and heterosexual (74%). A majority of
respondents were willing to use PrEP, if available (94%); however, 26%
suggested that they would be more likely to have unprotected sex with
HIV-positive partner while using PrEP and 27% suggested that it will be
difficult to take daily dose of PrEP and consistently use condoms as well. Multivariable
results suggested that 'inconsistent use
of condom with HIV-positive partner after knowing their status' was more
likely among males (aOR 10.43; 95% CI 2.67-40.79) and those with lower
education (aOR 6.09; 95% CI 1.59-23.41), whereas it was less likely
among those of older age (aOR 0.70; 95% CI 0.52-0.94) and MSM as compared to
heterosexuals (aOR 0.21; 95% CI 0.05-0.87); and perception 'condom is no longer needed while taking PrEP' was more likely
among those who did not use condom during last sexual intercourse (aOR 7.45;
95% CI 1.57-35.45) and less likely among those with higher HIV knowledge
score (aOR 0.43; 95% CI 0.23-0.78) .
Conclusions: There is high acceptability among seronegative partners for PrEP.
However, there is a substantial risk of sexual disinhibition and non-compliance
while using PrEP that may be reduced by ongoing education.
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