XIX International AIDS Conference

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TUPDC0302 - Poster Discussion Session


Perceptions and attitudes about PrEP among seronegative partners and the potential of sexual disinhibition associated with the use of PrEP

Presented by Wayne Duffus (United States).

A. Tripathi1, O. Whiteside2, C. Scanlon2, W. Duffus2


1University of South Carolina, Epidemiology and Biostatistics, Columbia, United States, 2South Carolina Department of Health and Environmental Control, Bureau of Disease Control, Columbia, United States

Background: Preexposure prophylaxis (PrEP) is a promising biomedical strategy to reduce HIV transmission. However, many caveats such as the potential risk of sexual disinhibition and non-compliance need to be considered. The objective of this survey was to explore the sociodemographic and behavioral factors associated with the adoption of PrEP among both MSM and heterosexual seronegative partners.
Methods: Pre-piloted self-administered survey was conducted among seronegative partners in a Ryan White Clinic in South Carolina from 2010-2011. Bivariate and multivariable analyses were used to explore the data.
Results: A total of 89 seronegative partners completed the survey. The median age was 42 years (IQR: 32-50) and a majority were males (56%), blacks (70%) and heterosexual (74%). A majority of respondents were willing to use PrEP, if available (94%); however, 26% suggested that they would be more likely to have unprotected sex with HIV-positive partner while using PrEP and 27% suggested that it will be difficult to take daily dose of PrEP and consistently use condoms as well. Multivariable results suggested that 'inconsistent use of condom with HIV-positive partner after knowing their status' was more likely among males (aOR 10.43; 95% CI 2.67-40.79) and those with lower education (aOR 6.09; 95% CI 1.59-23.41), whereas it was less likely among those of older age (aOR 0.70; 95% CI 0.52-0.94) and MSM as compared to heterosexuals (aOR 0.21; 95% CI 0.05-0.87); and perception 'condom is no longer needed while taking PrEP' was more likely among those who did not use condom during last sexual intercourse (aOR 7.45; 95% CI 1.57-35.45) and less likely among those with higher HIV knowledge score (aOR 0.43; 95% CI 0.23-0.78) .
Conclusions: There is high acceptability among seronegative partners for PrEP. However, there is a substantial risk of sexual disinhibition and non-compliance while using PrEP that may be reduced by ongoing education.

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