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Prevalence of cardiovascular risk factors in Spanish HIV-positive patients on antiretroviral therapy. The CORONATOR Study
V. Estrada1, J.I. Bernardino de la Serna2, J.L. Casado3, P. Domingo4, M. Masia5, J.A. Iribarren6, F. Lozano7, A. Rodriguez da Silva8, J. Olalla9, J. Santos10
1Hospital Clinico San Carlos, Madrid, Spain, 2Hospital La Paz, Madrid, Spain, 3Hospital Ramon y Cajal, Madrid, Spain, 4Hospital Santa Creu i Sant Pau, Barcelona, Spain, 5Hospital General Universitario de Elche, Elche, Spain, 6Hospital Donostia, San Sebastián, Spain, 7Hospital Universitario Virgen de Valme, Sevilla, Spain, 8CHUVI-Xeral, Vigo, Spain, 9Hospital Costa del Sol, Marbella, Spain, 10Hospital Virgen de la Victoria, Málaga, Spain
risk is a topic of increasing concern in the setting of HIV infection. Our
study aimed to estimate the risk of cardiovascular disease (CVD) in a representative sample of the population of HIV
patients who receive antiretroviral therapy in Spain.
analysis within 10 HIV units across Spain. We collected data on
demographics, HIV disease status and treatment history as well as
cardiovascular risk factors. Cardiovascular risk estimation was made by Regicor score (Framingham score adapted to Spain). This analysis describes the prevalence of
cardiovascular risk factors in our population.
were 895 subjects included, 100% on antiretroviral therapy with a median time since HIV diagnosis of 11 years
and median time on ART of 8 years. Median age was 46 y, 76.4% were male. Current median CD4 count (IQR)
was 597 c/mm3 (402-791) and 88% of the patients had HIV RNA< 50
cop/mL. 35 subjects (3.9%) reported a history of previous CVD. Table 1 shows
the prevalence of cardiovascular risk factors in our population.
| ||Total n=895|
|Age (men > 55 y, women > 65 y) n(%)||94 (10.5)|
|Cigarette smoking, n(%)||481 (54.0)|
|Hypertension, n(%)||280 (31.4)|
|Diabetes, n(%)||67 (7.6)|
|Total cholesterol > 240 mg/mL, n(%)||92 (10.5)|
|HDL-cholesterol < 40 mg/mL, n(%)||291 (33.3)|
|Total/HDL cholesterol ratio >5, n(%)||235 (26.9)|
|LDL-cholesterol > 160 mg/mL||71 (8.2)|
|Triglycerides > 200 mg/mL||191 (21.7)|
Other known risk factors include family history of
early CVD in 173 (20.0%) subjects, physical inactivity in 452 (59.8%) and
metabolic syndrome in 172 (19.6%). Renal function impairment (EPI4_CKD < 60 ml/min/1.73 m2) was
present in 41 subjects (4.7%). For those
subjects with no history of CVD (n=860), median value of Framingham-Regicor
Score (IQR) was 3% (2-4). The percentage of patients showing a moderate to high
10 years cardiovascular risk (>5%) was 22.2%.
found a high prevalence of traditional cardiovascular risk factors in this
population of Spanish patients with HIV infection. It seems advisable a more
aggressive management of modifiable CVD risk factors to prevent the occurrence
of cardiovascular disease in these patients.
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