XIX International AIDS Conference


WEAA02 HIV/SIV Pathogenesis
  Oral Abstract Session : Track A
Venue: Session Room 3
Time: 25.07.2012, 16:30 - 18:00
Co-Chairs: Martyn French, Australia
Ivona Pandrea, United States
 
 

16:30
WEAA0201
Therapeutic interventions to reduce microbial translocation and immune activation


I. Pandrea, United States

16:45
WEAA0202
Abstract
Powerpoint
Webcast
Differential SIV infection patterns of lymph node-resident CD4 T cells distinguishes progressive from nonprogressive SIV infection
C. Vinton1,2, J. Brenchley1,2, B. Tabb3, X.P. Hao4, V.M. Hirsch2, M. Paiardini5, J. Lifson3, G. Silvestri5, J.D. Estes3
1National Institute of Allergy and Infectious Diseases, National Institutes of Health, Program in Barrier Immunity and Repair and Immunopathogenesis Unit, Bethesda, United States, 2National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Molecular Microbiology, Bethesda, United States, 3National Cancer Institute, National Institutes of Health, AIDS and Cancer Virus Program, Frederick, United States, 4National Cancer Institute, National Institutes of Health, Pathology and Histotechnology Laboratory, Frederick, United States, 5Emory University, Atlanta, United States
C. Vinton, United States

17:00
WEAA0203
Abstract
Powerpoint
Webcast
Target cell restriction may limit mother-to-child transmission of SIV in sooty mangabeys
A. Chahroudi1,2, D. Carnathan2, P. Carnathan2, G. Silvestri2
1Emory University School of Medicine, Pediatrics, Atlanta, United States, 2Yerkes National Primate Research Center, Atlanta, United States
A. Chahroudi, United States

17:15
WEAA0204
Abstract
Powerpoint
Webcast
HIV-induced CD4 T cell depletion: an innate host defense gone awry?
G. Doitsh, N. Galloway, K. Monroe, Z. Yang, O. Zepeda, W.C. Greene
The J. David Gladstone Institutes, Virology and Immunology, San Francisco, United States
G. Doitsh, United States

17:30
WEAA0205
Abstract
Suppressor of cytokine signalling (SOCS) proteins are induced by IL-7 and the interaction of SOCS proteins with the IL-7 receptor alpha (CD127) may play a role in regulating CD127 expression in human CD8 T cells
F. Al-Ghazawi1,2, P. Parmar1,2, E. Faller1,2, S. Sugden1,2, N. Sant3, P. MacPherson1,2,3
1University of Ottawa, Biochemistry, Microbiology and Immunology, Ottawa, Canada, 2Ottawa Hospital Research Institute, Chronic and Infectious Diseases, Ottawa, Canada, 3Ottawa Hospital, Ottawa, Canada
F. Al-Ghazawi, Canada

17:55
CNIHR information slide


M. French, Australia

Powerpoints presentations
Differential SIV infection patterns of lymph node-resident CD4 T cells distinguishes progressive from nonprogressive SIV infection - Carol Vinton

Target cell restriction may limit mother-to-child transmission of SIV in sooty mangabeys - Ann Chahroudi

HIV-induced CD4 T cell depletion: an innate host defense gone awry? - Gilad Doitsh



Rapporteur report

Track A report by Jason Brenchley


The theme of this session was the discussion of emerging immunological dysfunctions in progressively HIV-infected humans and SIV-infected Asian macaques compared to naturally SIV-infected natural hosts. Dr. Ivona Pandrea (University of Pittsburg) discussed a novel therapeutic intervention to decrease microbial translocation-induced immune activation. She infected pigtail macaques with SIVagm and observed significant microbial translocation, cardiovascular disease, and immune activation in these animals. She then treated a subset of these SIVagm-infected pigtail macaques with rifaximin and sulfasalazine and noted that the treated animals had significantly reduced microbial translocation, inflammation and viral replication. Ms. Carol Vinton (NIAID, NIH) discussed cellular substrates for infection in natural hosts for SIV compared to nonnatural hosts for SIV. She found that lymph node resident and circulating peripheral blood CD4 T cell subsets were differentially targeted by SIV in naturally SIV-infected sooty mangabeys compared to progressively SIV-infected Asian macaques. Dr. Ann Chahroudi (Emory University) discussed how low numbers of target cells for SIV in young sooty mangabeys may limit vertical transmission in that natural host. She found very low frequencies of CCR5+ proliferating CD4 T cells in the mucosa of infant sooty mangabeys, potentially explaining the low incidence of vertical transmission in natural hosts for SIV. Dr. Gilad Doitsh (Gladstone Institute) discussed how depletion of CD4 T cells in HIV-infected individuals may be, in part, attributed to activation of infected CD4 T cells. He used in vitro infection of lymph node cultures and showed that the majority of HIV-infected cells are abortively HIV infected and that their death was attributed to activation-induced pyroptosis instead of direct virus-mediated killing and that this activation-induced death could be blocked by the FDA approved drug glimepiride. Mr. Feras Al-Ghazawi (University of Ottowa) discussed how IL-7 signalling may lead to a feedback inhibition of future IL-7 signals. He found IL-7 induced expression of SOCS1-3 and significant down-regulation of the IL-7 receptor CD127. He then showed by coimmunoprecipitation that SOCS proteins may lead directly to down-regulation of CD127.




   

    The organizers reserve the right to amend the programme.


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